Maximizing human developmental


Here, you can view the most recent findings and publications of the LifeCycle research team. Just click on the respective title to read or download the original article.

Number of LifeCyle publications to date: 35


  1. Alemany S., Jansen P.R., Muetzel R.L. et al. (2019) Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population. Journal of the American Academy of Child and Adolescent Psychiatry, online first: S0890-8567(19)30007-3
  2. den Dekker H.T., Burrows K., Felix J.F. et al. (2019) Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course. European Respiratory Journal, online first: 53(3): 1801795
  3. Haworth S., Shapland C.Y., Hayward C. et al. (2019) Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. Nature Communications, online first: 10(1): 357
  4. Jacob C.M., Cooper C., Baird J., Hanson M. (2019) What quantitative and qualitative methods have been developed to measure the implementation of a life-course approach in public health policies at the national level? in Health Evidence Network synthesis report 63. Copenhagen. Publisher: WHO Europe
  5. Reese S.E., Xu C.-J., den Dekker H.T. et al. (2019) Epigenome-wide meta-analysis of DNA methylation and childhood asthma. The Journal of Allergy and Clinical Immunology, online first: pp. 1-13
  6. Voerman E., Santos S., Golab B.P. et al. (2019) Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis. PLOS Medicine, online first: 16(2): e1002744


  1. Beaumont R.N., Warrington N.M., Cavadino A., Tyrrell J., Nodzenski M., Horikoshi M., et al. (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet. 27(4): 742-56
  2. Björkqvist J., Pesonen A.K., Kuula L., Matinolli H.M., Lano A., Sipola-Leppanen M., et al. (2018). Premature birth and circadian preference in young adulthood: evidence from two birth cohorts. Chronobiol Int. 35(4): 555-64
  3. Casas M., den Dekker H.T., Kruithof C.J., Reiss I.K., Vrijheid M., Sunyer J., et al. (2018). The effect of early growth patterns and lung function on the development of childhood asthma: a population based study. Thorax. Published Online First: 31 July 2018
  4. Contreras Z.A., Chen Z., Roumeliotaki T. et al. (2018) Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. European Respiratory Journal, online first: 52(3):
  5. Demenais F., Margaritte-Jeannin P., Barnes K.C., Cookson W.O.C., Altmuller J., Ang W., et al. (2018). Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 50(1): 42-53
  6. den Dekker H.T., Jaddoe V.W.V., Reiss I.K., de Jongste J.C., Duijts L. (2018). Fetal and Infant Growth Patterns and Risk of Lower Lung Function and Asthma. The Generation R Study. Am J Respir Crit Care Med. 197(2): 183-92
  7. Felix J.F., Cecil C.A.M. (2018). Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework. J Dev Orig Health Dis. Published Online First: 13 August 2018
  8. Felix J.F., Joubert B.R., Baccarelli A.A., Sharp G.C., Almqvist C., Annesi-Maesano I., et al. (2018). Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol. 47(1): 22-3u
  9. Gaillard R., Wright J., Jaddoe V.W.V. (2018) Lifestyle intervention strategies in early life to improve pregnancy outcomes and long-term health of offspring: a narrative review. Journal of Developmental Origins of Health and Disease, online first. pp. 1-8
  10. Golab B.P., Santos S., Voerman E., Lawlor D.A., Jaddoe V.W.V., Gaillard R. (2018) Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. The Lancet Child & Adolescent Health, 2(11): pp. 812-821
  11. Guxens M., Lubczyńska M.J., Muetzel R.L., Dalmau-Bueno A., Jaddoe V.W.V., Hoek G., et al. (2018). Air Pollution Exposure During Fetal Life, Brain Morphology, and Cognitive Function in School-Age Children. Biological Psychiatry. 84(4): 295-303
  12. Magnus M.C., Miliku K., Bauer A., Engel S.M., Felix J.F., Jaddoe V.W.V., et al. (2018). Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study. Bmj. 361: k2167
  13. McEachan R.R.C., Yang T.C., Roberts H., Pickett K.E., Arseneau-Powell D., Gidlow C.J., et al. (2018). Availability, use of, and satisfaction with green space, and children’s mental wellbeing at age 4 years in a multicultural, deprived, urban area: results from the Born in Bradford cohort study. Lancet Planet Health. 2(6): e244-e54
  14. Santos S., Eekhout I., Voerman E., et. al. (2018) Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. BMC Medicine, 16(201), online first: pp. 1-15
  15. Santos S., Zugna D., Pizzi C., Richiardi L. Sources of confounding in life course epidemiology. Journal of Developmental Origins of Health and Disease, online first: pp. 1-7
  16. Sharp G.C., Arathimos R., Reese S.E., Page C.M., Felix J., Kupers L.K., et al. (2018). Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts. Epigenomics. 10(1): 27-42
  17. van Meel E.R., den Dekker H.T., Elbert N.J., Jansen P.W., Moll H.A., Reiss I.K., et al. (2018). A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma. Thorax. 73(2):167-73
  18. Vehmeijer F.O.L., Guxens M., Duijts L., El Marroun H. (2018) Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review. Journal of Developmental Origins of Health and Disease, online first: pp. 1-12
  19. Waage J., Standl M., Curtin J.A., Jessen L.E., Thorsen J., Tian C., et al. (2018). Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 50(8): 1072-80
  20. Warrington N.M., Richmond R., Fenstra B., Myhre R., Gaillard R., Paternoster L., et al. (2018). Maternal and fetal genetic contribution to gestational weight gain. Int J Obes (Lond). 42(4): 775-84
  21. Wilmink F.A., den Dekker H.T., de Jongste J.C., Reiss I.K.M., Jaddoe V.W.V., Steegers E.A., Duijts L. (2018) Maternal blood pressure and hypertensive disorders during pregnancy and childhood respiratory morbidity: the Generation R Study. European Respiratory Journal, online first: 52(5):
  22. Zugna D., Richiardi L. (2018). Effects decomposition in mediation analysis: a numerical example. Epidemiol Prev. 42(2): 127-33


  1. Herzog E.M., Eggink A.J., Willemsen S.P., Slieker R.C., Wijnands K.P.J., Felix J.F., et al. (2017). Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn. Placenta. 58: 122-32
  2. Lubczynska M.J., Sunyer J., Tiemeier H., Porta D., Kasper-Sonnenberg M., Jaddoe V.W.V., et al. (2017). Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts. Environ Int. 109: 170-80
  3. Popovic M., Fasanelli F., Fiano V., Biggeri A., Richiardi L. (2017). Increased correlation between methylation sites in epigenome-wide replication studies: impact on analysis and results. Epigenomics, Volume 9, pp. 1489-1502
  4. Rautio N., Filatova S., Lehtiniemi H., Miettunen J. (2017) Living environment and its relationship to depressive mood: A systematic review. International Journal of Social Psychiatry, 64(1): pp. 92-103
  5. Richmond R.C., Timpson N.J., Felix J.F., Palmer T., Gaillard R., McMahon G., et al. (2017). Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study. PLoS Med. 14(1): e1002221
  6. Sharp G.C., Salas L.A., Monnereau C., Allard C., Yousefi P., Everson T.M., et al. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Hum Mol Genet. 26(20): 4067-85
  7. van Meel E.R., Jaddoe V.W.V, Bonnelykke K., de Jongste J.C., Duijts L. (2017). The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review. Pediatr Pulmonol. 52(10): 1363-70