Maximizing human developmental


Here, you can view the most recent findings and publications of the LifeCycle research team. Just click on the respective title to read or download the original article.

Number of LifeCyle publications to date: 24

currently in press:

Contreras ZA, Chen Z, Roumeliotaki T, Annesi-Masesano I, Baïz N, Von Berg A, et al. Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. European Respiratory Journal [in press]

Santos S, Zugna D, Pizzi C, Richiardi L. Sources of confounding in life course epidemiology. J Dev Orig Health Dis [in press]

Vehmeijer FOL, Guxens M, Duijts L, El Marroun H. Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review. Journal of Developmental Origins of Health and Disease [in press]


  1. Felix J.F., Cecil C.A.M. (2018). Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework. J Dev Orig Health Dis. Published Online First: 13 August 2018
  2. Casas M., den Dekker H.T., Kruithof C.J., Reiss I.K., Vrijheid M., Sunyer J., et al. (2018). The effect of early growth patterns and lung function on the development of childhood asthma: a population based study. Thorax. Published Online First: 31 July 2018
  3. Waage J., Standl M., Curtin J.A., Jessen L.E., Thorsen J., Tian C., et al. (2018). Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 50(8): 1072-80
  4. Magnus M.C., Miliku K., Bauer A., Engel S.M., Felix J.F., Jaddoe V.W.V., et al. (2018). Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study. Bmj. 361: k2167
  5. McEachan R.R.C., Yang T.C., Roberts H., Pickett K.E., Arseneau-Powell D., Gidlow C.J., et al. (2018). Availability, use of, and satisfaction with green space, and children’s mental wellbeing at age 4 years in a multicultural, deprived, urban area: results from the Born in Bradford cohort study. Lancet Planet Health. 2(6): e244-e54
  6. Beaumont R.N., Warrington N.M., Cavadino A., Tyrrell J., Nodzenski M., Horikoshi M., et al. (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet. 27(4): 742-56
  7. Björkqvist J., Pesonen A.K., Kuula L., Matinolli H.M., Lano A., Sipola-Leppanen M., et al. (2018). Premature birth and circadian preference in young adulthood: evidence from two birth cohorts. Chronobiol Int. 35(4): 555-64
  8. Guxens M., Lubczyńska M.J., Muetzel R.L., Dalmau-Bueno A., Jaddoe V.W.V., Hoek G., et al. (2018). Air Pollution Exposure During Fetal Life, Brain Morphology, and Cognitive Function in School-Age Children. Biological Psychiatry. 84(4): 295-303
  9. Zugna D., Richiardi L. (2018). Effects decomposition in mediation analysis: a numerical example. Epidemiol Prev. 42(2): 127-33
  10. Felix J.F., Joubert B.R., Baccarelli A.A., Sharp G.C., Almqvist C., Annesi-Maesano I., et al. (2018). Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol. 47(1): 22-3u
  11. Demenais F., Margaritte-Jeannin P., Barnes K.C., Cookson W.O.C., Altmuller J., Ang W., et al. (2018). Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 50(1): 42-53
  12. van Meel E.R., den Dekker H.T., Elbert N.J., Jansen P.W., Moll H.A., Reiss I.K., et al. (2018). A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma. Thorax. 73(2):167-73
  13. Warrington N.M., Richmond R., Fenstra B., Myhre R., Gaillard R., Paternoster L., et al. (2018). Maternal and fetal genetic contribution to gestational weight gain. Int J Obes (Lond). 42(4): 775-84
  14. den Dekker H.T., Jaddoe V.W.V., Reiss I.K., de Jongste J.C., Duijts L. (2018). Fetal and Infant Growth Patterns and Risk of Lower Lung Function and Asthma. The Generation R Study. Am J Respir Crit Care Med. 197(2): 183-92
  15. Sharp G.C., Arathimos R., Reese S.E., Page C.M., Felix J., Kupers L.K., et al. (2018). Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts. Epigenomics. 10(1): 27-42


  1. Popovic M., Fasanelli F., Fiano V., Biggeri A., Richiardi L. (2017). Increased correlation between methylation sites in epigenome-wide replication studies: impact on analysis and results. Epigenomics, Volume 9, pp. 1489-1502
  2. Richmond R.C., Timpson N.J., Felix J.F., Palmer T., Gaillard R., McMahon G., et al. (2017). Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study. PLoS Med. 14(1): e1002221
  3. van Meel E.R., Jaddoe V.W.V, Bonnelykke K., de Jongste J.C., Duijts L. (2017). The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review. Pediatr Pulmonol. 52(10): 1363-70
  4. Lubczynska M.J., Sunyer J., Tiemeier H., Porta D., Kasper-Sonnenberg M., Jaddoe V.W.V., et al. (2017). Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts. Environ Int. 109: 170-80
  5. Sharp G.C., Salas L.A., Monnereau C., Allard C., Yousefi P., Everson T.M., et al. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Hum Mol Genet. 26(20): 4067-85
  6. Herzog E.M., Eggink A.J., Willemsen S.P., Slieker R.C., Wijnands K.P.J., Felix J.F., et al. (2017). Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn. Placenta. 58: 122-32

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